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KMID : 1011820200610030297
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Investigative and Clinical Urology
2020 Volume.61 No. 3 p.297 ~ p.303
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Expression of bladder α1-adrenoceptor subtype after relief of partial bladder outlet obstruction in a rat model
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Lee Ji-Yong
Park Jong-Mok
Na Yong-Gil
Song Ki-Hak
Lim Jae-Sung
Yang Seung-Woo
Kim Gun-Hwa
Shin Ju-Hyun
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Abstract
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Purpose: Many patients with benign prostatic hyperplasia require treatment for persistent storage symptoms, even when the obstruction is successfully relieved by surgery. Previous studies identified a characteristic increase in α1D-adrenoceptor levels in the bladder in a bladder outlet obstruction (BOO) model. Here, we investigated the expression of α1-adrenoceptor subtypes in the bladder after relief of partial BOO (pBOO) in a rat model.
Materials and Methods: A total of 60 female Sprague?Dawley rats were randomly divided into three groups (sham-operated, pBOO, and pBOO relief groups), and the expression of α1-adrenoceptor subtypes in the urothelium and detrusor muscle tissues was examined by western blot.
Results: The expression of the α1D-adrenoceptor was significantly higher in the urothelium and detrusor muscle tissue of the pBOO and pBOO relief groups than in the corresponding tissue of the sham-operated group. Additionally, the α1A-adrenoceptor was predominant in the sham-operated group but significantly decreased in the urothelium in the pBOO group. No significant differences were found in α1A-adrenoceptor levels in detrusor muscle or whole bladder.
Conclusions: Our results showed that α1D-adrenoceptor levels were consistently increased with pBOO, even after relief, suggesting that the α1D-adrenoceptor might be a cause of persistent storage symptoms after relief of pBOO.
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KEYWORD
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Adrenergic alpha-1 receptor antagonists, Lower urinary tract symptoms, Urinary bladder neck obstruction, Urinary bladder, overactive
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